In addition to the deputies, the Lake County Sheriff says two people in the home died and one other was injured.
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The state says traffic is backed up for at least seven miles to mile marker 345.
The sheriff’s office says those arrested include a little league coach, an employee of Kids Central and illegal aliens.
Gainesville police say 36-year-old Troy Robinson served nearly a year behind bars for similar crimes against women and had just gotten out a week before the most recent cases.
Deputies arrested 30-year-old Kevin Sharkey and 33-year-old Shonda Sharkey following the pursuit.
A security camera across the street from Classic Laundromat captured the explosion.
Four people were injured in the blast. Emergency crews transported two to the hospital. Remarkably, no one died.